It feels like over 95% of Upwork job owners want to pay less while expecting high value, especially when the freelancer is from Middle Eastern or Asian countries. What can I do to truly stand out and get paid fairly, especially targeting US/Canada clients?

You're right about the pattern — Western clients often assume they'll get outsized leverage from working with someone in a lower cost-of-living country, and for the most part that assumption is rooted in real cost-of-living arbitrage, not racism (though it still often results in your work being unfairly assumed to be lower quality). You'll be fighting against that the whole way through, and there's no way to fully eliminate it short of working with clients entirely outside that dynamic — but you can lessen it. Two big things: (1) Raise your rate — the biggest immediate signal of 'cheap offshore labor' is a low headline rate (e.g. $5-15/hr on Upwork); charge like $45-65/hr, competitive with Western freelancers, instead. (2) Understand Western working-culture norms — they tend to be blunter, more direct, and (from my experience employing people across a dozen+ countries) they generally like agency and initiative much more than excessive deference. A common issue with hires from lower cost-of-living countries is being reluctant to voice opinions or take initiative for fear of being off-putting — but Western clients tend to respond well to it. So instead of constantly asking permission, act, then explain afterward if needed, rather than asking 'should I do this?' at every step.